Information about nootropics and our brainformula NZT.2

Nootropic is derived from a combination of two greek words, "nous", meaning mind and "trepein" meaning to bend. Nootropics are substances supposed to bend the mind to a higher level of functioning. Nootropics can have an effect on the brain through many pathways and levels of functioning. they can increase supply of oxygen and nutritions to the brain. They can increase or chance availabiity of neurotransmitters. On this page we explore several. Nootropics take as a goal to increase concentration and memory, reasoning, clear the mind and reduce mental stress.


These are nootropics that generally influence adrenergic, dopaminergic and noradrenergic systems in the body and central nervous system. These systems play a keyrole in alertness, concentration and motivation. Famous substances from this class are ampheatmines. . Amphetamines block the reuptake of dopamine and noradrenalin in this way keeping these substances longer available in the synaptic cleft between communicating neurons. The neurotransmitters act longer and stimulate nerve activity that is involved in activating the brain, especially parts involved in executive functioning, motivation and drive. A part of this is the prefrontal cortex, in this part higher cognitive functioning takes place, like organizing and planning, thinking about thinking. A disadvantage of stimulants is the dependency they can create, especially when they have a fast effect. One will need more and more of the substance to get the same effect. Also caffeine is considered a stimulant, yet from a totally other class, caffeine mainly works physically but also partly mentally.
For NZT.2 we chose a caffeine free blend. Caffine is certainly stimulating and increases focus to a certain extend. the downside is the jitteriness it creates. By chosing a refined combination of substances we were able to make a formula that increases concentration, focus and mental energy without causing jiteriness feelings or nervousness. As an option NZT.2 can be taken together with coffee. For some people this is a good combination, the coffee will boost the NZT.2 in a synergetical way. Substances in NZT.1 to improve concentration are ginseng, rhodiola rosea, DMAE, vitamin B12 and vitamin B6. Ginkgo biloba needs special attention, this herb is a so called NRI, it means a NoradrenalineReuptakeInhibitor, by blocking the reuptake of noradrenaline it will stay longer active and will boost the noradenergic system.

Dopaminergic substances

The dopamingeric system in the brain is involved in concentration, focus, attention and general arousal. This system projects nervetracks in general to frontal brainparts. Dopamingeric substances increase dopamine or activate in other ways this system, dopamine is also an important anti-oxidant in the brain. Dopaminergic substances overlap with stimulants. NZT.2 includes a herb called Rhodiola Rosea, it is known to be a so called MAO-B inhibitor. MAO is short for Mono Aminen, dopamine is one of these. By blocking reuptake of dopamine it will act longer on the nerve cell. Rhodiola is known to have an uplifting effect, increases energy when fatigued and calmes down in stress. These benefits can be related to the MAO-B inhibitor in this herb. Rhodiola rosea can be considered a good nootropic. Also L-theanine is known to boost dopamine levels in the brain.

Serotoneric substances

the serotonergic system is involved in moodregulation in the brain, and possibly also neurogenesis (growth of neurons). By influencing the serotonergic system somebody can get a better mood. By inhibiting MAO-A, a subclass of MAO, serotonine will act longer and this affects the mood, it can uplift the mood. NZT.2 contains two MAO-A inhibitors, namely curcumin and piperine. Another compund of NZT.2, l-theanine has also been shown to increase serotonine levels.

Adaptogenes | Anti stress

Adaptogenes are substances that protect the body for non-specific stress. They are not meant to treat specific diseases or conditions, but they boost the general resistance of the body. Thet are not directly considered nootropics, but by relieving stress they can inndirectly boost cognition. On the other hand some adaptogens seem to have a direct nootropical effect. NZT.2 contains a lot of adaptogens, ginseng, rhodiola rosea, ginkgo biloba and bacopa monnieri, we are fond of these substances for there subtle but singificant effect on general and cognitive well-being. Exact mechanisms are not completely known, but for many adaptogens there is research on specific effects. They seem to act on neurotransmitters and besides this ginseng seems to have a stabilizing effect on the adrenal glands. Due to many substances in these adaptogens their mechanisms are complex. Sometimes the effect is exaggerated. For instance ginseng is shown to have only small effect on physical level. As for the mental level ginseng seems to improve several functions including response time and motorical skills. It generally is experienced as stimulating. Ginkgo Biloba is also one of our favorites, it energizes and gives a clear feeling in the head. Rhodiola Rosea seems to be uplifting, energizing while at the same time calming down. Bacopa sharpens the mind, it's the ultimate brainfog eliminator.

GABAergic substances

GABA-ergic sustances act on the GABA system in the brain, an inhibitory system. Due to it's inhibitory nature it has a rol in anti-stress. The GABA system inhibits excitatory nerve activity, many medicine for epilepsy act on this system, since epilepsy is a disinhibition of neuronal activity. In NZT.2 we included l-theanine. This substance acts on the GABA-system in the brain. Subjectively it gives a feeling of relaxation, but at the same time a clear feeling in the head. By using l-theanine we balance the excitatory compunds in NZT.2 like DMAE and Alpha-GPC with a calming effect. It took us a long time to balance this, NZT.1 gives a focussed, energetic yet calm and comfortabel feeling. We didn't use a high dosage since this can cause tiredness and in some even a headache. L-theanine is a subtle yet indispensable substance in NZT.2.


Ginkgo biloba acts as a vasodilator (veins and capillaries open more) and besides this is a NRI (noradrenaline reuptake inhibitor). There are both positive studies about ginseng in relation to memory in adults. But there is solid evidence of ginkgo having a positive effect on selective attention, executive functioning and short-term memory.